Clinical history:
33 year old man with severe fatigue. WBC: 1,200. HCT: 33%. PLT: 15,000.
Cytogenetics:
Hyperdiploid karyotype – The finding of >50 chromosomes defines a subcategory of B-ALL with a unique gene expression profile and good prognosis.
Read more on B-lymphoblastic leukemia with hyperdiploidy (bone marrow – biopsy)…
Clinical history:
21 y/o male. WBC 3.9 HCT 35.4, PLT 46
Bone marrow aspirate:
Monomorphic B-lymphoblasts comprise the majority of cells.
Clinical history:
56 year old man with weight loss and bleeding. WBC: 7,200 (10% blasts were identified at outside hospital).
Cytogenetics:
t(8;22) – This translocation involves the loci for MYC (8q24) and lambda light chain (22q11). It is less common in BL than the t(8;14), which involves the IGH locus.
Clinical history:
56 year old man with weight loss and bleeding. WBC: 7,200 (10% blasts were identified at outside hospital).
Immunohistochemistry:
