Slides in the "Small intestine" Category

Amyloidosis, duodenal

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79 year old with gastric tumor and long history of gastritis and duodenitis.

Celiac sprue

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Female in her 30’s with iron deficiency anemia. Duodenal biopsy.

Cholchicine toxicity

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MICROSCOPIC FEATURES

• Numerous metaphase mitoses in crypt epithelium, especially “ring” mitoses
• There may also be epithelial pseudostratification, loss of goblet cell polarity, villus blunting, and increased apoptotic figures

DIFFERENTIAL DIAGNOSIS

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Collagenous sprue

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65 year old with clinical picture of celiac disease, unresponsive to gluten-free diet.

Cystic fibrosis (colon)

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19 yo with small intestinal obstruction. Ileal mass was surgically removed

Giardiasis

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MICROSCOPIC FEATURES

Giardia lamblia trophozoites (pear-shaped organisms, sometimes with two nuclei) seen on the luminal surface, with no tissue invasion
• Usually normal-appearing intestinal mucosa, but can sometimes see villous blunting, and a mixed inflammatory infiltrate in the lamina propria (neutrophils, lymphocytes, and plasma cells)

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Non-small cell lung carcinoma, metastatic to small bowel

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70 M small bowel mass

Severely active chronic ilieitis with granulomas (Crohn’s disease)

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9 y/o M with iron deficiency anemia, weight loss, and diarrhea. Biopsy of terminal ileum.