Amyloidosis, duodenal
79 year old with gastric tumor and long history of gastritis and duodenitis.
79 year old with gastric tumor and long history of gastritis and duodenitis.
Female in her 30’s with iron deficiency anemia. Duodenal biopsy.
MICROSCOPIC FEATURES
• Numerous metaphase mitoses in crypt epithelium, especially “ring” mitoses
• There may also be epithelial pseudostratification, loss of goblet cell polarity, villus blunting, and increased apoptotic figures
DIFFERENTIAL DIAGNOSIS
65 year old with clinical picture of celiac disease, unresponsive to gluten-free diet.
19 yo with small intestinal obstruction. Ileal mass was surgically removed
MICROSCOPIC FEATURES
• Giardia lamblia trophozoites (pear-shaped organisms, sometimes with two nuclei) seen on the luminal surface, with no tissue invasion
• Usually normal-appearing intestinal mucosa, but can sometimes see villous blunting, and a mixed inflammatory infiltrate in the lamina propria (neutrophils, lymphocytes, and plasma cells)
70 M small bowel mass
9 y/o M with iron deficiency anemia, weight loss, and diarrhea. Biopsy of terminal ileum.