Slides in the "Esophagus" Category
Barrett’s esophagus, with high-grade dysplasia, non-adenoma-like
View Slide
MISCELLANEOUS
- IHC confirmed a gastric phenotype of the dysplastic glands (positive for MUC5AC and negative for MUC2), corresponding to the “non-adenoma-like” type. p53 was also positive, while p16 was negative.
Candida esophagitis
View Slide
MICROSCOPIC FEATURES
- Superficial acute inflammation in the squamous epithelium
- Keratotic debris and fibrinopurulent exudates are commonly seen
- Organisms may be seen by H+E (round yeast forms and pseudohyphae)
DIFFERENTIAL DIAGNOSIS
- Herpes esophagitis
Candida esophagitis
View Slide
Female with dysphagia
Candida esophagitis
View Slide
Male with dysphagia
Chronic esophagitis with granulomas (Crohn’s disease)
View Slide
9 y/o M with iron deficiency anemia, weight loss, and diarrhea. Biopsy of distal esophagus
Foveolar dysplasia, high-grade
View Slide
64 yo M with Barrett’s esophagus. Esophageal biopsy.
Granular cell tumor
View Slide
Female in her 30’s with an esophageal ulcer. Esophageal biopsy.
Lymphocytic esophagitis, c/w Crohn’s disease
View Slide
Adolescent male with gastrointestinal complaints. Esophageal biopsy.
Squamous papilloma
View Slide
MICROSCOPIC FEATURES
• Nodular proliferation of squamous epithelium with fibrovascular cores of lamina propria
• Squamous epithelium shows acanthosis, a prominent basal layer, and complete surface maturation
• The epithelium may also exhibit koilocytosis, parakeratosis, dyskeratosis, and prominent granular cell layer, but overall the cytology is bland
• The lamina propria shows acute and chronic inflammation and vascular congestion
• Three types are recognized: exophytic (most common), endophytic, and spiked or verrucoid (least common)