Ganglion cyst of peripheral nerve
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No history
Slides in the "Neurogenic lesions" Category
Granular cell tumor
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No history
Lipofibromatous hamartoma
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No history
Malignant peripheral nerve sheath tumor, arising in a plexiform neurofibroma
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23 y/o male with an NF1 mutation and intrathoracic masses
Malignant peripheral nerve sheath tumor, with rhabdomyoblastic differentiation
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No history
Neurofibroma, diffuse type
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No history
Neurofibroma, plexiform type
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No history
Perineurioma, sclerosing epithelioid variant
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Clinical history
28 y/o male with a thumb mass
Immunohistochemistry
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- Claudin – positive in a minority of perineuiomas, but relatively specific
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- EMA – positive in nearly all perineuriomas
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- Keratin – lack of tumor cell expression rules out carcinoma or epithelioid sarcoma
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- NKC13 – May be positive in perineurioma, but is nonspecific
Perineuroma, sclerosing variant
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Soft tissue, excision
Schwannoma
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No history
Schwannoma
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Female in her 60’s with a thyroid nodule
Schwannoma, cellular type
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No history
Schwannoma, plexiform type
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No history
Schwannoma, with ancient change
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No history
Schwannoma, with ancient change
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Male in his 40’s with a leg mass
Schwannoma, with cystic and ancient change
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Female in her 90’s with bilateral arm masses
Schwannoma, with cystic and ancient changes
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97 y/o female with masses on both arms
Traumatic neuroma
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41 y/o female with painful finger mass