Virtual Slidebox
Presented by the MGH Pathology Service

Clinical summary
43 y/o female with a liver mass

Clinical summary
35 y/o female with a pancreatic mass

57 y/o female with a right renal mass

Clinical summary
61 y/o female, lung nodule

Clinical summary
64 y/o female, lung mass

Clinical summary
65 y/o female, lung mass

Clinical summary
26 y/o male, lung nodules

Clinical summary
72 y/o male, groin mass

Clinical summary
33 y/o male, mediastinal lymphadenopathy and history of tongue cancer

Clinical summary
76 y/o female, tracheal mass

Clinical summary
73 y/o male, lung mass

Clinical summary
53 y/o male, renal mass

Clinical summary
47 y/o male, renal mass

Clinical summary
53 y/o female, nasal mass

Clinical history:

82 y/o male, lung mass

Suggested frozen diagnosis:

“Metastatic adenocarcinoma”

Clinical issues:

Mediastinal node staging is often done immediately prior to a planned definitive surgical resection for pulmonary carcinoma. Involvement of N2 nodes (levels 1-9, beyond the visceral pleura of the lung) is usually a contraindication for lobectomy or pneumonectomy. Missing a metastasis in these nodes on frozen may result in a futile surgical procedure, and substantial unnecessary morbidity to the patient. Unlike isolated mediastinal lymphadenopathy (possible lymphoma workup), staging nodes should be frozen entirely.

Read more on Pulmonary adenocarcinoma, metastatic (mediastinal lymph node)…

Clinical summary
62 y/o female, knee mass

Clinical summary
57 y/o male, pharyngeal lesion

Clinical summary
67 y/o male, peritoneal nodule

Clinical summary
92 y/o female, axillary mass

Clinical summary
58 y/o male, subcutaneous flank lesion

Clinical summary
81 y/o male, diffuse lymphadenopathy

Clinical summary
77 y/o male, cervical lymphadenopathy

Clinical summary
37 y/o female, liver mass

Clinical summary
83 y/o male, distal pancreatic mass, gastric wall nodule

Clinical summary
83 y/o male, distal pancreatic mass, liver lesion

Clinical summary
76 y/o male, glottic lesion

Clinical summary
76 y/o male, glottic lesion

Clinical summary
76 y/o male, glottic lesion

Clinical summary
57 y/o male, parotid mass

Clinical summary
59 y/o male, thyroid nodule

Clinical summary
19 y/o male, testicular mass

Comment:
This tumor resembles seminoma on frozen section.

Clinical summary
80 y/o male, thigh mass

Clinical summary
66 y/o male, gluteal mass

AKA
Hemangiopericytoma

48 y/o female, knee mass

Clinical summary
60 y/o female, lower leg nodule

Clinical summary
42 y/o female, humerus lesion

Clinical summary
White female with two yellow papules on right thigh x 1 year, increasing in size, asymptomatic. Xanthoma vs. xanthogranuloma.

61 y/o female with arm lesion

ddx: intraepidermal cyst

Clinical summary
2.0 cm pedunculated papule; DDX: nevus, neurofibroma.

Clinical summary
60 y/o male with a non-healing chest wound. History of local radiation therapy for lymphoma.

Clinical summary
93 y/o male with a left ear nodule. Clinical impression: cyst.

Clinical summary
13 y/o female with a left arm pigmented lesion. Clinical impression: Rule out dysplastic nevus.

Clinical summary
58 y/o female with right breast lesion. Clinical impression: irritated nevus.

70 y/o male with papules on cheek and lip. Clinical impression: hyperplasia vs. fibrous papule

Clinical summary
Cervical Pap

Clinical summary
65 year old gentleman with history of MF (diagnosed in El Salvador). Biopsy to confirm CTCL with progression to Sézary syndrome.

Clinical summary
69 yo male, NFD/NFS vs. morphea.

Clinical summary
60 y/o female with a sacral mass

Clinical summary
73 y/o male, thigh mass

Clinical summary
45 yo woman with 3 cm finger mass